There might be the scenario where you will be looking for computers which doesnt have particular application installed on.Create a new collection and copy the below simple WQL query which list you all computers there by you can advertise the application package onto it.
select SMS_G_System_SYSTEM.Name from SMS_R_System inner join SMS_G_System_SYSTEM on SMS_G_System_SYSTEM.ResourceID = SMS_R_System.ResourceId where SMS_G_System_SYSTEM.Name not in (select SMS_G_System_SYSTEM.Name from SMS_R_System inner join SMS_G_System_SYSTEM on SMS_G_System_SYSTEM.ResourceID = SMS_R_System.ResourceId inner join SMS_G_System_ADD_REMOVE_PROGRAMS on SMS_G_System_ADD_REMOVE_PROGRAMS.ResourceID = SMS_R_System.ResourceId where SMS_G_System_ADD_REMOVE_PROGRAMS.DisplayName like “Adobe acrobat reader“)
change the application(adobe actobat reader) the one you are looking at.